K. Akaji, Makoto Yoshida, T. Tatsumi
1990
Citations
0
Influential Citations
15
Citations
Journal
Journal of The Chemical Society, Chemical Communications
Abstract
Tetrafluoroboric acid in trifluoroacetic acid, in the presence of thioanisole, has been found to cleave various protecting groups currently employed in Fmoc-based (Fmoc = fluoren-9-ylmethoxycarbonyl) solid-phase peptide synthesis without significant side reactions; this new deprotecting reagent has been successfully applied to the solid-phase synthesis of human glucagon (a 29 residue peptide) and α-MSH (a 13 residue peptide amide, acetyl-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2).