M. Shevchuk, J. Sotiropoulos, K. Miqueu
Jun 1, 2011
Citations
0
Influential Citations
4
Citations
Journal
Synlett
Abstract
A straightforward synthesis of highly functionalized 2-aminoethylidene-1,1-bisphosphonicacids via the Michael addition of amines to easily available tetrakis(trimethylsilyl)ethenylidene-1,1-bisphosphonate, H 2 C=C[P(O)(OTMS) 2 ] 2 ,has been described. The potassium salts of the title compounds werealso easily achieved in high yield by reacting the Michael adductswith potassium fluoride.