R. Quiroz-Segoviano, M. A. García-Sánchez, N. Delgado-Buenrostro
Oct 1, 2019
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0
Influential Citations
4
Citations
Quality indicators
Journal
Journal of Drug Delivery Science and Technology
Abstract
Abstract Tetraphenylporphyrin (H2TPP), was synthesized and characterized by UV and FTIR spectroscopy. H2TPP was included in a solution (Labrasol™:Transcutol™ 1:2 v/v) and in a microemulsion (whose composition was chosen from the construction of pseudo-ternary diagrams). Permeation experiments were performed with these two systems through intact skin and skin pretreated with sonophoresis. Confocal laser scanning microscopy was useful to evidence that in all cases, H2TPP penetrated the interior of the skin, increasing the amount that penetrates when the skin was treated with sonophoresis, especially for the combination sonophoresis/microemulsion, with which the highest permeated amount was achieved. In no case, H2TPP was found in the receptor medium, which may be desirable if the aim is to reduce a systemic effect. The results obtained suggest that the proposed systems have potential application in photodynamic therapy, whose effectiveness depends on the penetration and accumulation of photosensitizer in the affected tissue.