G. P. Hager, J. Krantz, J. Harmon
1953
Citations
0
Influential Citations
3
Citations
Journal
Journal of the American Pharmaceutical Association. American Pharmaceutical Association
Abstract
8-Benzyltheophylline is analogous from a structural standpoint to the synthetic adrenergic-blocking agent, Priscoline, and was prepared along with various related compounds with the hope that the resulting hybridization of structural characteristics would result in an agent useful clinically in treatment of hypertension. The following compounds are reported: 8-benzyltheophylline; 8-(2-methylene-2-imidazoline)-theophylline; 7-benzyltheophylline; and 7-(2-methylene-2-imidazoline)-theophylline. 8-Benzyltheophylline in preliminary pharmacologic tests showed promise of being a potent hypotensive agent, and current studies have as their objective an elaboration of the structure of 8-benzyltheophylline in order to provide a basis for correlation of structure and activity.