V. Biton, J. Gates, F. Ritter
Aug 1, 1990
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Influential Citations
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Journal
Epilepsia
Abstract
Summary: In a retrospective study, records of 46 patients (24 women and 22 men aged 17–51 years; mean 29.2 years), who had been treated with ethotoin (EHN) as adjunctive therapy for control of intractable seizures were reviewed. Overall, ∽51% of this highly selected patient population had a reduction >50% in overall seizure frequency 1 month after initiation of treatment. This was reduced to ∽25% for the last 3 months of follow‐up (mean follow‐up period 10.6 months). Tonic seizure frequency was reduced most dramatically, by >50%, in 60% of patients at 1 month and in 35% of patients for the last 3 months of follow‐up. This study suggests that prospective controlled trials of EHN, especially for tonic seizures, are needed.