X. Zhai, G. Brezesinski, H. Möhwald
Sep 2, 2004
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0
Influential Citations
19
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Journal
Journal of Physical Chemistry B
Abstract
Monolayers of newly synthesized amide phospholipids, 1-O-hexadecyl-2-N-palmitoyl-2-amino-2-deoxy-sn-glycero-3-phosphocholine (l-ether-amide-PC) and 1-palmitoyl-2-N-palmitoyl-2-amino-2-deoxy-sn-glycero-3-phosphocholine (l-ester-amide-PC) were investigated at the air/subphase interface by Brewster angle microscopy combined with a conventional LB trough and Grazing incidence X-ray diffraction (GIXD). Both systems investigated exhibit two-dimensional domains with characteristic shape in the coexistence region between liquid-expanded (LE) and liquid-condensed (LC) phases. Especially l-ether-amide-PC shows highly chiral domains depending on temperature. The largest chiral domains (400 μm) growing in a clockwise direction are obtained at 25 °C. Such large domains have rarely been observed for phospholipids before. Thermodynamic data derived from π−A isotherms provide information about critical temperature (Tc) and phase transition enthalpy (ΔH) for both amide phospholipids. The amide group leads to pronounced di...