N. Chen, A. Zinchenko, S. Kidoaki
Mar 2, 2010
Citations
0
Influential Citations
10
Citations
Journal
Langmuir : the ACS journal of surfaces and colloids
Abstract
We used poly(N-isopropylacrylamide) (PNIPAM) to control the conformation of genomic DNA by changing the temperature of a reaction solution and studied the DNA transition at the level of single DNA molecules. With this method, the conformation of long genomic DNA can be readily and reversibly switched between a very compact condensate and an unfolded macromolecule.