Shoubhik Das, Felix D. Bobbink, Safak Bulut
Feb 2, 2016
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Influential Citations
94
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Quality indicators
Journal
Chemical communications
Abstract
The catalytic N-formylation and N-methylation of amines using CO2 as the carbon source represents a facile and sustainable approach for the synthesis of pharmaceuticals and natural products. Herein, we describe highly effective and inexpensive thiazolium carbene-based catalysts derived from vitamin B1 for the N-formylation and N-methylation of amines, using polymethylhydrosiloxane (PMHS) as a reducing agent, which operate under ambient conditions.