I. Taraporewala
1991
Citations
0
Influential Citations
21
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Structural simplification of pentacyclic and hexacyclic antiviral and anti-tumor acridine alkaloids such as dercitin, cyclodercitin and kuanoniamine led to the identification of the thiazo[5,4-b]acridine or the isomeric thiazolo[4,5-b]acridine nucleus as the putative pharmacophore. Synthetic approaches towards these tetracyclic ring systems and regiochemistry of the thiazole ring in cyclodehydration reactions are discussed.