Eman Z Elrazaz, Rabah A T Serya, N. S. Ismail
Dec 1, 2015
Citations
1
Influential Citations
46
Citations
Journal
Future Journal of Pharmaceutical Sciences
Abstract
Abstract Thienopyrimidines are fused heterocyclic ring systems; structurally resemble purines, exerting pharmacological potential in different aspects. They are known to play a crucial role in various disease conditions. Thieno[2,3- d ]pyrimidine derivatives have been explored for their inhibitory activities towards various protein kinase enzymes. The present review is a compilation on chemical synthesis and biological anticancer significance, via inhibition of specific protein kinase enzymes, including structure–activity relationships of thieno[2,3- d ]pyrimidines derivatives reported to date.