Daniel N. Do Amaral
2013
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Abstract
Thionyl chloride is a colorless l iquid (sometimes pale yellow due to impuri ties ), molecular weight 118.97, boi ling point 76 °C, soluble in carbon tetrachloride, benzene and chloroform, density 1.631 g.cm -3 and smell resembling that of sulfur dioxide (SO2). This reagent is highly versatile and is used in severa l synthetic methodologies to obtain several intermediaries and chemicals of interest in agrochemistry, fine chemistry and pharmacy. The industrial production of thionyl chloride is expensive and speci fic faci l i ties are required to conta in and handle the reagents, products and impurities in an eco -friendly manner. Several methodologies of production of this reagent are described and most of them use sul fur oxides . Thionyl chloride must be carefully ha ndled, because this reagent can cause irritation and severe burns to eyes, membranes and skin.