C. Landreau, D. Deniaud, A. Reliquet
Feb 1, 2003
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Influential Citations
12
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Journal
European Journal of Organic Chemistry
Abstract
We report here the first example of an efficient regioselective synthesis of heterobicyclic compounds using thiourea as starting material. The key step in this synthetic process is the preparation of N,N′-bis[(dimethylamino)methylene]thiourea (1), which reacts as thiazadiene, leading to diazadiene heterocycles. These heterocycles give either thiazolopyrimidine 4 or imidazo-1,3-thiazine 7 by a double annulation reaction. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)