Tao Li, Pinglin Li, Xiangchao Luo
Jul 25, 2019
Citations
1
Influential Citations
9
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Three new dibromopyrrole alkaloids, 9- N -methylcylindradine A ( 1 ), 1- N -methylugibohlin ( 2 ), nemoechine H ( 3 ), together with one known dibromopyrrole alkaloid N -methyldibromoisophakellin ( 4 ) were isolated from the South China Sea sponge Agelas nemoechinata . Their structures were elucidated by comprehensive spectroscopic methods including HRESIMS and NMR, and the absolute configuration of compound 1 was further confirmed by comparison of optical rotation. Compound 3 exhibited moderate cytotoxic activity against K562 and L-02 with IC 50 values of 6.1 μ M and 12.3 μ M, respectively.