Rajesh H. Vekariya, Kinjal D. Patel, D. Rajani
Jun 1, 2017
Citations
2
Influential Citations
21
Citations
Journal
Journal of the Association of Arab Universities for Basic and Applied Sciences
Abstract
Abstract A convenient, one-pot, multi-component protocol for the preparation of 2-(1-(2-oxo-2H-chromen-3-yl)ethylidene)hydrazinecarbothioamide derivatives has been achieved. Here, firstly we have reported the synthesis of 3-acetyl-2H-chromen-2-one using starch sulfuric acid and cellulose sulfuric acid as biodegradable catalysts. Subsequently, we also carried out the reaction of isothiocynates, hydrazine hydrate and 3-acetyl-2H-chromen-2-one in the presence of catalytic amount of glacial acetic acid in refluxing ethanol to afford corresponding 2-(1-(2-oxo-2H-chromen-3-yl)ethylidene)hydrazinecarbothioamide derivatives in high to excellent yields. All synthesized compounds were screened for antimicrobial activity. All compounds were found to show good to excellent activity against Escherichia coli MTCC 443.