M. Ghandi, N. Zarezadeh, Abuzar Taheri
Jun 27, 2012
Citations
0
Influential Citations
18
Citations
Journal
Tetrahedron Letters
Abstract
2-(3-Chloro-2-formyl-1H-indol-1-yl) acetic acid, as a bifunctional formyl-acid, is prepared in three steps. This compound undergoes a one-pot, four-center, three-component Ugi reaction with primary amines and alkyl isocyanides. A series of novel substituted indoloketopiperazine derivatives are obtained in moderate to high yields.