A. Solladié-Cavallo*, J.S.P. Schwarz, C. Mouza
May 28, 1998
Citations
0
Influential Citations
44
Citations
Journal
Tetrahedron Letters
Abstract
Abstract (R)-2-Methyltryptophan ethyl ester, (R)-2, having an enantiomeric purity >,=96% was obtained in 3 steps and using (SSS)-hydroxypinanone, 1, as the recoverable chiral auxiliary. The synthesis of the alkylating agent, 5a, was improved (to a reproduceble 55% overall yield from 2,3-dimethylindole). The resolution of racemic-2 through chromatographic separation of the corresponding iminoester derived from (RRR)-1 also proved to be easy and efficient (∼25% yield).