Gisele R. Paim, H. Bonacorso, E. Pittaluga
Sep 1, 2013
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Abstract
Secondary amines bearing a heteroaryl scaffold are well known for their applications in the chemical industry as basic intermediates to prepare fine chemicals, pharmaceuticals and agrochemicals. In addition, their remarkable biological properties confer to them an import role in the chemotherapy of a variety of diseases. 1 Pyrazole and its derivatives are compounds whose synthesis, reactivity and bioactivity as anti-inflammatory, analgesic and anesthetic have been well explored. 2 On the other hand the presence of the trifluoromethyl group (CF3) attached to heterocycles, has provided significant changes in their chemical, physical, spectroscopic 3