L. Bao, M. Loda, P. Janmey
Dec 1, 1996
Citations
1
Influential Citations
136
Citations
Quality indicators
Journal
Nature Medicine
Abstract
The Dunning rat prostatic carcinoma is a model system where cell motility closely correlates with the metastatic phenotype. We have identified a novel gene, upregulated in the highly motile and metastatic Dunning cancer cell lines, that represents a new member of the thymosin–beta family, thymosin β15. Transfection of antisense thymosin β15 constructs into rat prostatic carcinoma cells demonstrates that this molecule positively regulates cell motility, a critical component of the metastatic pathway. Thymosin β15 levels are elevated in human prostate cancer and correlate positively with the Gleason tumor grade. Thymosin β15 may represent a potential new biochemical marker for human prostate cancer progression.