A. Hanyaloglu, K. Eidne
2008
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Abstract
The tripeptide, thyrotropin-releasing hormone (L-pyroglutamyl-L-histidyl-L-prolinamide) acts on its receptors in the thyrotrope and lactotrope cells to promote secretion of TSH and prolactin, respectively. Aside from its well-known endocrine role in the thyroid system, TRH receptors are also thought to act as modulatory neuropeptides in the central nervous system. The cloning of a second receptor for TRH from rat brain and spinal cord provided a possible explanation for certain neurotransmitter actions of TRH, in particular the nociceptive and spinal cord regenerative actions. The two TRH receptor subtypes, TRH1 and TRH2, are found in several species, however, to date, the TRH2 receptor has not yet been identified in humans.