Nastassia A. Varabyeva, M. Barysevich, Y. Aniskevich
Jun 25, 2021
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0
Influential Citations
8
Citations
Journal
Organic letters
Abstract
Readily available from esters or ketones, cyclopropanols are inclined to undergo diverse ring-opening transformations. Their one-electron oxidation is a conventional way to β-carbonyl radicals. However, despite this fact, their application as a coupling partner in dual photoredox and nickel-catalyzed reactions with organic halides remains underdeveloped. Here, we report that the Ti(OiPr)4 additive enables this elusive cross-coupling with aryl and alkenyl bromides leading to β-substituted ketones.