H. Mizutani, Toshimichi Yoshida, N. Nouchi
Jan 1, 1999
Citations
0
Influential Citations
39
Citations
Quality indicators
Journal
The Journal of Dermatology
Abstract
Four patients with systemic scleroderma (SSc), 4 patients with morphea, and 4 patients with hypertrophic scar were treated with topical tocoretinate for 6 months to 3 years and studied clinically and histopathologically. Clinically, all of the lesions responded to this therapy. The stiffness of the skin lesions, glossy appearance of the lesions, and telangiectasia improved. Histopathologically, the proliferated collagen fibers decreased in thickness, and the inter‐fiber spaces increased. Immunoreactive tenascin‐C expressed in the proliferated deep dermal fibers of the SSc and hypertrophic scar lesions was markedly decreased compared with the level before the topical tocoretinate therapy.