Hussein N. Rubaiy, M. J. Ludlow, K. Siems
Jun 28, 2018
Citations
0
Influential Citations
13
Citations
Journal
British Journal of Pharmacology
Abstract
The diterpene ester tonantzitlolone (TZL) is a natural product, which displays cytotoxicity towards certain types of cancer cell such as renal cell carcinoma cells. The effect is similar to that of (‐)‐englerin A, and so, although it is chemically distinct, we investigated whether TZL also targets transient receptor potential canonical (TRPC) channels of the 1, 4 and 5 type (TRPC1/4/5 channels).