O. Onomura, M. Mitsuda, M. Nguyen
Dec 24, 2007
Citations
0
Influential Citations
32
Citations
Journal
Tetrahedron Letters
Abstract
Kinetic resolution of 2-hydroxyalkanamides was performed by tosylation in the presence of copper(II) triflate and (R,R)-Ph-BOX as a catalyst. This method was successfully applied to a variety of 2-hydroxyalkanamides in high enantioselectivity with up to 92% ee, and then tosylated product was easily transformed into optically active α-amino acid derivatives.