V. Shekhar, D. K. Reddy, S. P. Reddy
Aug 1, 2011
Citations
0
Influential Citations
16
Citations
Journal
European Journal of Organic Chemistry
Abstract
A simple and efficient stereoselective total synthesis of desacetylumuravumbolide (1a) and umuravumbolide (1b), starting from commercially available valeraldehyde has been described. The synthetic strategy involves a highly enantioselective zinc-mediated addition of protected 2 alkyn-1-ol to aldehyde, a Crimmins aldol reaction, and Horner–Wadsworth–Emmons olefination as key steps.