Hiroto Kaku, Natsuko Okamoto, Takeshi Nishii
Sep 1, 2010
Citations
0
Influential Citations
11
Citations
Journal
Synthesis
Abstract
According to the concept of thermodynamically controlled deracemization, racemic 2-(2-methoxyethyl)cyclohexanone was converted into the R-isomer (99% ee) in 90% yield using (-)-(2R,3R)-trans-2,3-bis(hydroxydiphenylmethyl)-1,4-dioxaspiro[5.4]decane as a host molecule under basic conditions. As an application, a short and enantioselective synthesis of (R)-α-lipoic acid was accomplished in 44% overall yield from (±)-2-(2-methoxyethyl)cyclohexanone.