L. Alinari
Mar 30, 2017
Citations
0
Influential Citations
8
Citations
Journal
Blood
Abstract
In this issue of Blood, Gayle et al provide evidence that apilimod, a potent and selective phosphatidylinositol-3-phosphate 5 kinase (PIKfyve) inhibitor, induces significant cytotoxicity at clinically achievable concentrations in preclinical models of B-cell non-Hodgkin lymphoma (NHL) via inhibition of the autophagy flux and perturbation of lysosome homeostasis.1