Andree Iemhoff, James Sherwood, C. McElroy
Jan 2, 2018
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Influential Citations
38
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Journal
Green Chemistry
Abstract
The esterification of 2-phenylpropionic acid was investigated as a model system for enzyme catalysed (CALB, Novozyme 435) reactions in bio-based solvents. A multi-parameter correlation taking into account solvent parameters was developed to explain experimental observations. A continuous flow process using p-cymene as the solvent was operated over several weeks, thus combining a sustainable solvent and flow chemistry for kinetic resolution.