P. Abreu, J. Pastre, Luiz F. T. Novaes
Feb 15, 2019
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Revista dos Trabalhos de Iniciação Científica da UNICAMP
Abstract
Cacospongia sp. is a species of marine sponge that produces labdane-class diterpens known as Cacofurans A and B, which show cytotoxic activity in vitro. In this work, we present the synthetic pathway of Cacofurans A and B in ten and nine steps, respectively. Five steps of the synthetic proposal were completed, with 25% overall yield, including the formation of a five-membered ring using the Suárez reaction. After the completion of the total synthesis, the cytotoxic potential of Cacofurans A and B will be evaluated.