A. Shwetha, B. Hosetti, P. Dube
Jun 1, 2012
Citations
1
Influential Citations
21
Citations
Journal
International Journal of Environmental Research
Abstract
Effect of zinc cyanide on protein and certain metabolites content and some enzymes activitieswas evaluated in liver, muscle and gill tissues of the freshwater fish, Cirrhinus mrigala, during exposure andfollowing cessation of exposure. Fish exhibited significant alterations in the biochemical parameters in alltissues studied. Levels of total protein decreased in all tissues, where as free amino acids (FAA) and proteaseactivities significantly increased (P<0.05). Similarly decrease was observed in the ammonia level with increasedurea and glutamine levels at all exposure periods. The enzymes involved in the protein metabolism alteredunder the zinc cyanide intoxication. Increase in the protease and aminotransferases revealed amplifiedtransamination processes. Significant increase of phosphatases indicated increased rate of phosphorylationand transport of molecules across the cell membrane. Withdrawal study also exhibited significant recovery inall above biochemical parameters, in all tissue after the 7th day post recovery treatment. Present studyexhibited negative effects of zinc cyanide on protein metabolism. Fish with low protein content were not fitfor human consumption. Patterns of effects on intermediary metabolism suggest avenues to determine themechanisms by which such effects occur.