J. Gray, R. N. Weaver, J. A. Bollert
Apr 1, 1972
Citations
0
Influential Citations
21
Citations
Quality indicators
Journal
Toxicology and applied pharmacology
Abstract
Abstract The potoxicities of clindamycin hydrochloride and clindamycin palmitate have been extensively studied in mice, rats and dogs. For the hydrochloride, the ip mouse and po rat LD50 values were 361 and 2618 mg/kg, respectively. The values for the palmitate ester were >2500 and >5000 mg/kg; in a formulated syrup the po LD50 was reduced to 1950 mg/kg. The maximum daily tolerated dose of the hydrochloride in the dog and rat for as long as 1 yr was greater than 300 mg/kg but less than 600 mg/kg. Significant changes in bioclinical data in dogs treated with 300 mg/kg were confined to sporadic elevations in serum transaminase levels. At 600 mg/kg, in short-term studies, the effects of focal irritation were recognized in the mucosa of the stomach and gallbladder of the dog. No teratogenic effect or developmental retardation in the offspring of mouse or rat dams, or effect on the breeding performance of male and female rats was observed. In a comparable series of studies with the palmitate ester, essentially no effects due to the antibiotic were detected. A daily dose of 600 mg/kg was well tolerated in the dog and rat for 6 mo.