Y. Edlund, L. Zettergren
Jun 1, 1961
Citations
1
Influential Citations
4
Citations
Journal
Acta Radiologica
Abstract
The evolution of agents for the selective examination of the gallbladder has during recent decades passed from compounds containing one iodine atom bound to an aromatic nucleus to compounds containing three iodine atoms with the same nucleus. This has resulted in the availability of a series ofvaluable diagnostic contrast media. Compounds containing four iodine atoms in an aromatic ring constitute the next step; a number of these are described in the literature although little is known about their toxic properties. Investigating the reaction between tetra-iodophthalic acid anhydride and secondary amines, SKAGIUS & EKEMARK prepared the methylglucamine salt of tetra-iodophthalic acid morpholide (Ph 761/3, Pharmacia, Uppsala, Sweden). In rabbits, Ph 761/3 has shown promising properties as a roentgen diagnostic agent for intravenous cholegraphy (NOVEK); it produced a high content of iodine in the biliary flow although most of it was excreted via the kidneys. It was deemed interesting, in the light of these results, to study the action of Ph 761/3 on hepatic and renal tissues.