J. W. Harrison, J. Madonia
Jul 1, 1971
Citations
1
Influential Citations
51
Citations
Quality indicators
Journal
Oral surgery, oral medicine, and oral pathology
Abstract
Abstract The toxicity of reduced concentrations of parachlorophenol in an aqueous vehicle has been compared to that of camphorated parachlorophenol and other intracanal medications. Microscopic studies and conjunctival inflammatory tests indicated that a 1 per cent aqueous parachlorophenol solution evokes a very mild connective tissue inflammatory response, whereas camphorated parachlorophenol is a highly toxic preparation capable of causing tissue necrosis. The low toxicity potential and the previously demonstrated antimicrobial effectiveness of 1 per cent aqueous parachlorophenol suggest the possibility of clinical advantages in reducing acute “flare-ups” caused by overmedication during root canal therapy.