J. Li
2004
Citations
0
Influential Citations
3
Citations
Quality indicators
Journal
Chinese Journal of Natural Medicines
Abstract
AIM: To test the toxic effects of clivorine,monocrotaline,isoline,platyphylline,yamataimine and 12-acetyl yamataimine pyrrolizidine alkaloids isolated from Ligularia and Monocrotalia on hepatocytes.METHOD: Using MTT experiment to test the effect of these pyrrolizidine alkaloids on hepatocytes.Using crystal violet staining assay to make a further validation of the toxic effect of clivorine.RESULT:Clivorine had toxic effect on hepatocytes and other pyrrolizidine alkaloids had no effect on hepatocytes.The crystal violet staining assay confirmed clivorine's toxic effect.CONCLUSION:Clivorine has direct toxic effect on hepatocytes.