D. Conine, M. Yum, R. Martz
Jul 1, 1975
Citations
1
Influential Citations
21
Citations
Quality indicators
Journal
Toxicology and applied pharmacology
Abstract
The toxicity of sodium pentafluorostannite (NaSn2F5) in mice and rats has been investigated. LD50 values in mice were 18.9, 80.9, and 592.9 mg/kg in fed mice dosed iv, ip, and po, respectively. Signs of toxicity in mice included ataxia, muscle weakness, central nervous system depression, and occasionally tremors. LD50 values in female rats were 12.9, 65.0, and 218.7 mg/kg in fed rats dosed iv and ip and in fasted rats dosed po, respectively. LD50 values in male rats were 12.9, 75.4, 573.1, and 223.1 mg/kg in fed rats dosed iv, ip, and po and in fasted rats dosed po, respectively. Signs, accompanying toxic doses of NaSn2F5, sodium fluoride (NaF), or stannous chloride (SnCl2·2H2O) in the rat were similar and included ataxia, muscle weakness, and CNS depression. Sodium pentafluorostannite was found to be more toxic than either NaF, based on F, or SnCl2·2H2O, based on Sn. Rats given either Sn compound developed pathologic changes in the kidneys grossly visible 4 days following administration. The data suggest that both F and Sn play a role in the acute toxicity of NaSn2F5 in rats.