G. A. Pollock, C. E. DiSabatino, R. C. Heimsch
1982
Citations
2
Influential Citations
31
Citations
Quality indicators
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Abstract
Alternariol monomethyl ether (AME), a metabolite of species of Alternaria, was studied for subchronic toxicity to rats and teratogenic effects in golden hamsters. In rats no toxic effects were observed at the highest dosage tested (3.75 mg given by oral gavage daily for 30 days). However, AME was maternally toxic and foetotoxic to Syrian golden hamsters when given ip at 200 mg/kg body weight on day 8 of gestation. No such effects were observed at dose levels of 50 or 100 mg/kg.