T. Tusing, O. E. Paynter, D L Opdyke
May 1, 1962
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0
Influential Citations
24
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Quality indicators
Journal
Toxicology and applied pharmacology
Abstract
The acute and chronic toxicity of sodium lauryl glyceryl ether sulfonate and sodium lauryl trioxyethylene sulfate have been studied in rats, and skin tumorigenicity has been investigated in mice. LD50 values determined by oral administration to rats were 1.82 g/kg for both compounds. Rats received the surface-active agents at levels of 0.1% and 0.5% in the diet for two years, with some animals sacrificed for examination at the end of one year. No adverse effects were observed in the experimental animals with respect to survival, growth, reproduction, food consumption, hematologic values, blood chemistry, or urine analyses. Microscopic evaluation of tissues revealed no pathogenic changes resulting from ingestion of the test materials. Scattered differences were found in organ: body weight ratios. No effects of the surfactants were observed in first or second generation offspring of the original animals. Twice-weekly application, for 105 weeks, of 5% aqueous solutions of sodium lauryl glyceryl ether sulfonate and sodium lauryl trioxyethylene sulfate to the skin of Swiss female mice did not lead to the development of skin tumors in any of the animals. Based on the results of these investigations there is no evidence that exposure to these two surfactants poses a toxic hazard to humans.