Kevin M. Klifto, P. Hanwright, J. Sacks
Jul 6, 2020
Citations
1
Influential Citations
4
Citations
Quality indicators
Journal
Plastic & Reconstructive Surgery
Abstract
Sir: T acid (trans-4-aminomethylcyclohexane1-carboxylic acid) is an antifibrinolytic medication considered by the World Health Organization as one of the most effective and safe medications needed in a health system.1 Its ability to limit intraoperative blood loss and reduce transfusion requirements without increasing the risk of deep venous thrombosis makes its use appealing for surgical patients.1 Its efficacy and safety have been explored in plastic surgery.2 Its indications and use are expanding rapidly, and it is increasingly likely that patients undergoing microvascular reconstruction will receive tranexamic acid during their hospital course. However, the effects of tranexamic acid on microvascular reconstruction remain unclear. To better elucidate these concerns, we reviewed the literature and identified three studies that evaluated the use of tranexamic acid in patients having flap-based reconstructive surgery (Table 1).3–5