Betty R. Lowry, A. C. Huitric
Apr 1, 1971
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0
Influential Citations
1
Citations
Journal
Journal of pharmaceutical sciences
Abstract
The N-methyl and N,N-dimethyl derivatives of cis- and trans-2-(3,4,5-trimethoxyphenyl)cyclohexylamines were prepared for evaluation of psychotropic activity, Synthesis by catalytic reductive methylation and characterization by NMR spectroscopy are reported. Magnetic nonequivalence of the methyl groups was observed in the trans-N,N-dimethyl derivative under acidic conditions where inversion of the nitrogen atom is suppressed.