Xiujuan Wu, Kristof J. Dubois, Joeri Rogiers
May 5, 2000
Citations
0
Influential Citations
13
Citations
Journal
Tetrahedron
Abstract
Abstract 2,(2),5,5-Tri- and tetrasubstituted analogues of 5-hydroxy-2-piperidinemethanol and 5-hydroxy-6-oxo-2-piperidinecarboxylic acid have been prepared via Diels–Alder reaction of 3-substituted 2H-1,4-oxazin-2-ones with ethene followed by functional group transformation of the resulting imidoyl chloride and lactone groups. Some of the 2-piperidinemethanol products are converted further into potential substance P antagonists.