E. Krajewska, D. Shugar
Jul 30, 1971
Citations
0
Influential Citations
20
Citations
Journal
Science
Abstract
Irradiation at 254 nm of aqueous solutions of 5-ethyl-, 5-propyl-, and 5-isopropyluracils (or their nulcleosides) leads to cleavage of the 5-alkyl substituents, via an intramolecular electrocyclic photoaddition intermediate, with formation of uracil (or its nucleoside). The plhotoaddition intermediates represent a new class of dihydropyrimidines, namely analogs of 5,6-dihydro-5,6-cyclobutanyluracil and its nucleosides; the biological significance is discussed.