K. A. Sayed, K. Orabi, D. Dunbar
May 6, 2002
Citations
0
Influential Citations
9
Citations
Journal
Tetrahedron
Abstract
Abstract Sarcophine ( 1 ) is a furanocembranoid diterpene first reported from the Red Sea soft coral Sarcophyton glaucum with remarkable yields of up to 3% dry weight. Semisynthetic transformation of the lactone to lactam in sarcophine by reaction with benzyl and ethylamine afforded six new N -substituted azasarcophines ( 2 – 7 ), in addition to an asymmetric novel dimer 8 . The in vitro activity of azasarcophines against Palsmodium falciparium (D6 clone) and P. falciparium (W2 clone) are also discussed.