M. T. Yazdi, Seyedeh Maryam Zanjanian, M. Faramarzi
Aug 1, 2006
Citations
0
Influential Citations
6
Citations
Journal
Archiv der Pharmazie
Abstract
Estr‐4‐en‐3,17‐dione II, 17β‐hydroxyestr‐4‐en‐3‐one III, 15α‐hydroxyestr‐4‐en‐3,17‐dione IV, and 15α,17β‐dihydroxyestr‐4‐en‐3‐one V were produced by microbial transformation of nandrolone decanoate I in the culture of Acremonium strictum PTCC 5282. Bioconversion characteristics observed were ester hydrolysis, oxidation, and hydroxylation. Each microbial product was purified chromatographically and characterized on the basis of spectral data obtained from 1H‐NMR, 13C‐NMR, FT‐IR, MS, and physical constants such as melting point and optical rotation.