Yixiong Wang, Lixia Chen, Feng Zhao
2011
Citations
0
Influential Citations
17
Citations
Journal
Journal of Molecular Catalysis B-enzymatic
Abstract
Abstract Microbial transformation of neoandrographolide ( 1 ), was performed by Mucor spinosus (AS 3.2450). Ten metabolites were obtained and identified as 14-deoxyandrographolide ( 2 ), 17,19-dihydroxy-8,13- ent -labdadien-16,15-olide ( 3 ), 3,14-dideoxyandrographolide ( 4 ), 7β-hydroxy-3,14-dideoxyandrographolide ( 5 ), 17,19-dihydroxy-7,13- ent -labdadien-16,15-olide ( 6 ), 8(17),13- ent -labdadien-16,15-olid-19-oic acid ( 7 ), 8α,17β-epoxy-3,14-dideoxyandrographolide ( 8 ), 8β,17,19-trihydroxy- ent -labd-13-en-16, 15-olide ( 9 ), phlogantholide-A ( 10 ), 19-[(β- d -glucopyranosyl)oxy]-19-oxo- ent -labda-8(17),13-dien-16,15-olide ( 11 ) by spectroscopic and chemical means. Among them, products 3 , 5 , 6 , 8 and 9 were characterized as new compounds. The inhibitory effects of compounds 1 – 11 on nitric oxide production in lipopolysaccharide-activated macrophages were evaluated and their preliminary structure–activity relationships (SAR) were discussed.