S. Becouarn, S. Czernecki, J. Valéry
Aug 1, 1995
Citations
0
Influential Citations
8
Citations
Journal
Nucleosides, Nucleotides & Nucleic Acids
Abstract
Abstract A new, high-yielding method for introduction of the selenophenyl residue at the 3′-position of thymidine is reported. This reaction avoided any strongly basic or reductive reagent, thus allowing the use of benzoate ester as a protective group at O-5′. Further oxidation-elimination sequence followed by basic deprotection afforded 2′,3′-didehydro-2′,3′-dideoxythymidine (D4T) in 67.5% overall yield from thymidine.