V. Askam, C. Baines, H. Smith
Mar 1, 1966
Citations
0
Influential Citations
12
Citations
Journal
Journal of Pharmacy and Pharmacology
Abstract
Methyl 11‐oxo‐18 β‐A‐neo‐oleana‐3, 12‐dien‐30‐oate and the corresponding 18α‐isomer have been prepared and tested for anti‐inflammatory and antidiuretic activity. Relative to methyl glycyrrhetinate, both kinds of activity and toxicity are reduced by the rearrangement. Features of interest in the nuclear magnetic resonance spectra of 18α‐ and 18 β‐derivatives of glycyrrhetinic acid are recorded.