N. H. Vo, C. Eyermann, C. Hodge
Nov 17, 1997
Citations
0
Influential Citations
35
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Trans-3-alkyl- or -arylcyclopropanecarboxylates, substituted in the 2-position with alkoxycarbonyl or nitrile groups, are efficiently prepared by coupling bromoacetic acid with Wang resin followed by pyridinium ylide formation and condensation of the ylide with ethylidene malonate derivatives. Good yields are obtained after cleaving the resin and esterifying the resulting cyclopropanecarboxylic acid with diazomethane. © 1997 DuPont Merck Pharmaceutical Company. Published by Elsevier Science Ltd.