Rajshekhar A Unhale, Nirmal K. Rana, V. Singh
Apr 10, 2013
Citations
0
Influential Citations
23
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Organocatalytic conjugate addition of thioacetic acid to a series of α-substituted N-acryloyloxazolidin-2-ones followed by enantioselective protonation has been studied in the presence of thiourea catalysts derived from cinchona alkaloids. Conjugate addition/protonation adducts have been obtained up to 97% ee and high yields. The methodology could serve as an easy and practical route to the syntheses of useful biologically active molecules.