Kishore Natte, H. Neumann, M. Beller
Jun 1, 2017
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Influential Citations
165
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Journal
Angewandte Chemie
Abstract
Methanol is used as a common solvent, cost-effective reagent, and sustainable feedstock for value-added chemicals, pharmaceuticals, and materials. Among the various applications, the utilization of methanol as a C1 source for the formation of carbon-carbon, carbon-nitrogen, and carbon-oxygen bonds continues to be important in organic synthesis and drug discovery. In particular, the synthesis of C-, N-, and O-methylated products is of central interest because these motifs are found in a large number of natural products as well as fine and bulk chemicals. In this Minireview, we summarize the utilization of methanol as a C1 source in methylation, methoxylation, formylation, methoxycarbonylation, and oxidative methyl ester formation reactions.