Cheng-Mi Huang, Jian Li, Shan-Le Wang
May 27, 2021
Citations
0
Influential Citations
5
Citations
Journal
The Journal of organic chemistry
Abstract
An efficient transition-metal-free decarboxylative cyclization of N-arylacrylamides with 2,2-difluoro-2-(phenylthio)acetic acid for the construction of thiodifluoroindoleone derivatives is described. This strategy features stable and readily available substrates, mild reaction conditions, and transition-metal-free catalysts. Notably, this protocol has successfully applied to synthesis of gem-difluoroalkenes, which exist in numerous biologically active compounds.