Y. Vara, T. Bello, E. Aldaba
Sep 25, 2008
Citations
0
Influential Citations
37
Citations
Journal
Organic letters
Abstract
The reaction between homophthalic anhydride and imines in the presence of TiCl4 and diisopropyl ethyl amine is trans-selective. Under these conditions, the reaction using homochiral imines can be highly diastereoselective, thus allowing the synthesis of enantiopure 1,2,3,4-tetrahydro-1-oxoquinoline-4-carboxylic acids.